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Amada Mrquez, una querida hija, hermana, ta y amiga, falleci el 28 de diciembre de 2024 a la temprana edad de 32 aos. Nacida en Houston, Texas, Amada fue profundamente amada por todos los que tuvieron el privilegio de conocerla.Amada llen... View Obituary & Service Information
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Dental caries is prevalent in spite of widespread use of mechanical and chemical plaque control methods. Streptococcus mutans is said to have a strong background in initiation of dental caries. Hence, exceptional methods are required which would be effective against dental caries. Current era is taking people back to traditional or herbal medicine, which is said to have comparatively better healing effects than synthetic drugs in the market.
Maximum zone of inhibition was found to be with C. amada compared to corresponding concentration of 0.2% chlorhexidine. Thus, inhibitory effect of C. amada is significantly better than 5%, 10% and 25% chlorhexidine mouthwash. The inhibitory effect increases as the concentration increases.
Dental caries remains the most prevalent disease of both children and adults even after widespread use of toothbrushes and toothpaste.[2] Hence, there is an emerging need to find a novel method which is more effective against dental caries. Literature suggests a strong involvement of Streptococcus mutans (S. mutans) in the initiation of dental caries.[1]
Chlorhexidine gluconate is one of the commercially available chemical mouthwashes, which is already proven to be an antibiotic and disinfectant. It is effective antimicrobial at 0.12 to 0.2% concentration and is used as gold standard control in various studies though it does have some side effects like permanent staining of teeth, mucosal erosion and dysgeusia.[3]
Medicinal plants have been used worldwide, since ages, with people preferring them due to easy availability, low cost, biocompatibility and lesser side effects compared to synthetic drugs. These include plants like neem, clove, babool, turmeric, etc., which have shown effective antimicrobial activity. Recently, there is a trend for use of herbal products in oral health care due to the presence of phytochemicals like alkaloids, essential oils, resins, glycosides, tannins and steroids.[4] One such plant with wide range of phytochemicals is Curcuma amada.
Curcuma amada Roxb. (Mango ginger) is a unique rhizome with morphological resemblance to ginger (zingiber officinale) but imparts a mango (mangifera indica) flavour. It belongs to the Zingiberaceae family and is known for preservative and medicinal values. The Ayurveda and Unani system of medicine has described its importance as appetizer, alexiteric, antipyretic, aphrodisiac and laxative. The name of this yellow-coloured spice is derived from Arabic word Kurkum which means yellow.[5,6,7]
Mango ginger when subjected to antibacterial guided purification by repeated silica gel chromatography yielded a pure compound after which it was named as amadaldehyde.[7] Various studies have suggested it as a novel compound which exhibits antibacterial activity against a